Longitudinal tracking of gait and balance impairments in cerebellar disease
Identifieur interne : 001C04 ( Main/Exploration ); précédent : 001C03; suivant : 001C05Longitudinal tracking of gait and balance impairments in cerebellar disease
Auteurs : Susanne M. Morton [États-Unis] ; Ya-Weng Tseng [États-Unis] ; Kathleen M. Zackowski [États-Unis] ; Jaclyn R. Daline [États-Unis] ; Amy J. Bastian [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-09-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Analysis of Variance, Ataxia, Cerebellar Diseases (physiopathology), Cerebellar disease, Cerebellum, Cerebellum (injuries), Cerebellum (physiopathology), Gait, Gait Ataxia (physiopathology), Humans, ICARS, Nervous system diseases, Neurologic Examination, Postural Balance, Sensitivity, Severity of Illness Index, Statistics, Nonparametric, Tracking, Walking, ataxia, cerebellum, clinical assessment, sensitivity, walking.
- MESH :
- injuries : Cerebellum.
- physiopathology : Cerebellar Diseases, Cerebellum, Gait Ataxia.
- Analysis of Variance, Gait, Humans, Neurologic Examination, Postural Balance, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society
Url:
- https://api.istex.fr/document/A488BA0B8496C7485584B370075B9669EAC69AC0/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939173
DOI: 10.1002/mds.23169
Affiliations:
- États-Unis
- Iowa, Maryland, Missouri (État), Pennsylvanie
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-09-15">2010-09-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1944">1944</biblScope><biblScope unit="page" to="1952">1952</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">A488BA0B8496C7485584B370075B9669EAC69AC0</idno><idno type="DOI">10.1002/mds.23169</idno><idno type="ArticleID">MDS23169</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Ataxia</term><term>Cerebellar Diseases (physiopathology)</term><term>Cerebellar disease</term><term>Cerebellum</term><term>Cerebellum (injuries)</term><term>Cerebellum (physiopathology)</term><term>Gait</term><term>Gait Ataxia (physiopathology)</term><term>Humans</term><term>ICARS</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Sensitivity</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term><term>Tracking</term><term>Walking</term><term>ataxia</term><term>cerebellum</term><term>clinical assessment</term><term>sensitivity</term><term>walking</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Cerebellum</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cerebellar Diseases</term><term>Cerebellum</term><term>Gait Ataxia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Gait</term><term>Humans</term><term>Neurologic Examination</term><term>Postural Balance</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ataxie</term><term>Cervelet</term><term>Marche à pied</term><term>Pathologie du système nerveux</term><term>Pathologie du cervelet</term><term>Pistage</term><term>Sensibilité</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cerebellar damage typically results in ataxia and can be caused by stroke, tumor, or one of many forms of degenerative disease. Since few pharmacological options are available, most treatments rely heavily on rehabilitation therapy. Little data exist on methods for tracking the progression of ataxia, which is critical for assessing the efficacy of current and newly developing treatments. Here, we tracked the severity of ataxia, with a particular emphasis on gait and balance dysfunction, in a group of individuals with cerebellar damage using the International Cooperative Ataxia Rating Scale (ICARS) and several instrumented laboratory measures of gait and balance impairments over 1 year. We found that the ICARS was able to distinguish between subjects with static lesions and those with degenerative disorders, was sensitive to increases in ataxia severity occurring over 1 year, and correlated well with specific instrumented measures of gait in persons with cerebellar degeneration. These results suggest the ICARS is a valuable tool for clinicians and investigators to document and track long‐term changes in gait and balance performance in individuals with cerebellar degenerative disorders. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li><li>Maryland</li><li>Missouri (État)</li><li>Pennsylvanie</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Morton, Susanne M" sort="Morton, Susanne M" uniqKey="Morton S" first="Susanne M." last="Morton">Susanne M. Morton</name></region><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Bastian, Amy J" sort="Bastian, Amy J" uniqKey="Bastian A" first="Amy J." last="Bastian">Amy J. Bastian</name><name sortKey="Daline, Jaclyn R" sort="Daline, Jaclyn R" uniqKey="Daline J" first="Jaclyn R." last="Daline">Jaclyn R. Daline</name><name sortKey="Tseng, Ya Eng" sort="Tseng, Ya Eng" uniqKey="Tseng Y" first="Ya-Weng" last="Tseng">Ya-Weng Tseng</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name><name sortKey="Zackowski, Kathleen M" sort="Zackowski, Kathleen M" uniqKey="Zackowski K" first="Kathleen M." last="Zackowski">Kathleen M. Zackowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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